Reports From Clinical Trail


Clinical Study of Acnacare

To see the effect of Acnacare on the treatment and prevention of acne, we conducted an open labeled clinical study in collaboration with Spin-Control France . This study aimed at evaluating over a 2 month- period the in vivo effect of an Acnacare oral supplement associated with an anti-acne Acnacare gel on healthy subjects who are suffering from acne grade 1 to 3 on acne grading scale.

Twenty (20) healthy female and male subjects were selected according to the inclusion/exclusion criteria of the study. All subjects gave their informed written consent before beginning the test. Three (3) additional subjects were selected in order to keep at least 20 people at the end of the study in case of subjects withdrawal.

Results of the Study

Analysis of the pairs of photographs blindly presented to one observer who tried to arrange in order the photographs as “before-after treatment” gave a mean score of 0.78 (0.42). We can conclude that a significant improvement in the facial appearance of acne lesions (both in the number of lesions and in their severities) has been observed after 2 months of use of the tested treatment.

A reduction in the number of lesions was observed in 15 out of 23 subjects.

Figure 1 presented thereafter illustrates the effect of the Acnacare oral supplement associated with the Acnacare gel obtained after 2 months of use.

 

Conclusion

Blind clinical evaluation of whole face photographs allowed demonstrating:

- A significant improvement in the facial appearance of acne lesions (both in the number of lesions and in their severities) after 2 months of use of the tested treatment.

Counting of the acne lesions on whole face photographs evidenced that:

- After 2 months of treatment, the mean number of acne lesions on the face of the subjects decreased significantly. A reduction in the number of lesions was observed in 15 out of 23 subjects.


Bibliography ( Published references )

•  Diane M. Thiboutot, John S. Strauss: Diseases of the Sebaceous Glands, in Dermatology in General Medicine, The McGraw-Hill Companies, 2003, p672-687.

•  Weimar VM, Puhl SC, Smith WH, et al. Zinc sulfate in acne vulgaris. Arch Dermatol. 1978;114:1776–1778

•  Hillstrom L, Pettersson L, Hellbe L, et al. Comparison of oral treatment with zinc sulphate and placebo in acne vulgaris. Br J Dermatol. 1977;97:681–684.

•  Micheal T.M., “Chapter 23: Chromium”. In: Encyclopedia of Nutritional Supplements. Prima Health: A division of Prima Publishing , USA , 194-198. 1996.

•  Keller, KL., and Fenske, NA., Uses of vitamin A, C and E related compounds in dermatology; A review. Journal of the American Academy of Dermatology 39:611-625, 1998.





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